Typically, the serum selenium concentration levels are significantly lower in women with gestational diabetes than in healthy pregnant women. The differences are especially remarkable in non-Caucasian pregnant women and in pregnant women in the third trimester. That is the finding of a recent meta-analysis and systematic review of the relevant literature from observational studies [Kong 2016].
Selenium and gestational diabetes
Gestational diabetes is defined as any degree of glucose intolerance that occurs with the onset of pregnancy. A physiological insulin resistance beginning in the second trimester and progressing through the third trimester is fairly typical of pregnancies. Expecting mothers generally need increased insulin secretion to maintain normal blood glucose levels. Impairment of the needed compensatory increases in insulin secretion leads to a diagnosis of gestational diabetes [Kong 2016].