Selenium and the prostate

Next to skin cancer, prostate cancer is the most common cancer in men in the United States. It is a leading causes of cancer death among men of all races and ethnic backgrounds. Low selenium status is associated with increased risk of prostate cancer.

There have been some recent research results relating to selenium supplementation and prostate gland tissue.  Researchers in The Netherlands have published results showing that a five-week daily intervention with a high-selenium yeast supplement, 300 micrograms daily, is associated with a down-regulation of genes that are involved with cellular growth and proliferation, with cellular immune response, and with inflammation processes.  Also down-regulated by the selenium supplementation is the activity of genes involved with wound-healing [Kok 2017].

The Dutch study was a randomized, double-blinded, placebo-controlled study.  Interestingly, the researchers saw the opposite effect in the placebo group.  In the placebo group, there was an up-regulation of the genes involved in cellular immune response [Kok 2017].

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Prostate cancer risk and selenium status

Selenium supplements in the form of organic high-selenium yeast tablets provide the best cancer chemo-protection. These supplements are made using the yeast species Saccharomyces cerevisiae in a selenium-enriched growth medium. The yeast cells that produce the high selenium yeast tablets are rendered inactive. They are killed off by a heating process. Strains of the same yeast species are used to brew beer and bake bread.

Selenium supplementation and the risk of prostate cancer?  What do we know?  We need to be careful in interpreting the research results that we have (and we need more research), but, yes, there is evidence for an inverse association between prostate cancer risk and selenium status [Hurst 2012].

As of this writing (April 2017), the protective effect of selenium supplementation against prostate cancer seems to be found in a relatively narrow range of plasma selenium status [Hurst 2012].  Furthermore, there seems to be a U-shaped relationship between selenium status and protection against prostate cancer.

If the concentrations of selenium in the plasma are too low, there is increased risk of prostate cancer.  This is a serious concern in many regions of the world.

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