{"id":1374,"date":"2019-08-15T11:59:57","date_gmt":"2019-08-15T11:59:57","guid":{"rendered":"https:\/\/seleniumfacts.com\/?p=1374"},"modified":"2019-08-19T07:00:05","modified_gmt":"2019-08-19T07:00:05","slug":"selenium-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/seleniumfacts.com\/index.php\/selenium-autoimmune-diseases","title":{"rendered":"Selenium and Autoimmune Diseases"},"content":{"rendered":"<figure id=\"attachment_1387\" aria-describedby=\"caption-attachment-1387\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1387 size-medium\" src=\"https:\/\/seleniumfacts.com\/wp-content\/uploads\/2019\/08\/Pain-300x203.png\" alt=\"\" width=\"300\" height=\"203\" srcset=\"https:\/\/seleniumfacts.com\/wp-content\/uploads\/2019\/08\/Pain-300x203.png 300w, https:\/\/seleniumfacts.com\/wp-content\/uploads\/2019\/08\/Pain.png 640w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-1387\" class=\"wp-caption-text\"><strong>Autoimmune diseases are conditions in which the person&#8217;s immune system mistakenly attacks parts of the person&#8217;s own body such as his or her joints or skin. There are as many as 14 common autoimmune diseases. Some attack only one organ; others attack the entire body. Through its role in the maintenance of thyroid function and its role in the antioxidant defense of cells and DNA, selenium may have a critical protective effect in the management of autoimmune diseases. More clinical research is needed.<\/strong><\/figcaption><\/figure>\n<p><strong>Selenium is a micronutrient that plays an important role in the oxidative defense of cells and DNA against damage by harmful free radicals.\u00a0 Selenium is the main component of the selenoproteins that play important roles in reproductive function, immune system modulation, and thyroid hormone synthesis [Sahebari].<\/strong><\/p>\n<h3>Low Serum Selenium Levels and Autoimmune Diseases<\/h3>\n<p>Decreased serum selenium levels have been associated with increased incidence of some autoimmune diseases.\u00a0 Furthermore, low levels of selenium may be a risk factor for systemic inflammation and for the initiation of some autoimmune diseases [Sahebari]:<\/p>\n<ul>\n<li>Rheumatoid arthritis<\/li>\n<li>Sj\u00f6gren syndrome<\/li>\n<li>Behcet&#8217;s diseases<\/li>\n<li>Scleroderma (systemic sclerosis)<\/li>\n<\/ul>\n<h3>Selenium Supplementation and Autoimmune Diseases<\/h3>\n<p>Selenium supplementation has been shown to have beneficial effects in <strong><em>the management of <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/rheumatoid-arthritis\/diagnosis-treatment\/drc-20353653\" target=\"_blank\" rel=\"noopener noreferrer\">rheumatoid arthritis<\/a><\/em><\/strong> and scleroderma [Sahebari].<\/p>\n<p>Selenium supplementation may reduce the incidence and severity of some other autoimmune diseases through its role in the maintenance of thyroid function and through its anti-inflammatory effects [Sahebari].<\/p>\n<p>There is a need for more clinical research into the impact of selenium supplementation on immune system function generally and into the impact of selenium supplementation on the risk of developing autoimmune diseases in particular [Sahebari].<\/p>\n<h3>Selenium and Autoimmune Diseases: The Evidence<\/h3>\n<p>Researchers reviewed the results of 32 published medical journal articles on the topic of <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30324883\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>selenium and autoimmune diseases.<\/strong><\/em><\/a>\u00a0 A majority of the articles showed an improvement in the clinical symptoms of autoimmune diseases after treatment of patients with varying dosages of l-selenomethionine, which is the primary species of selenium found in high-selenium yeast preparations [Sahebari].<\/p>\n<p>The researchers&#8217; review of the medical journal literature showed that low serum selenium concentrations are not uncommon in patients with autoimmune diseases [Sahebari].<\/p>\n<p>At present, it is not clear whether the selenium deficiency found in patients with autoimmune diseases is a cause or a consequence (or both) of the development of the autoimmune diseases [Sahebari].<\/p>\n<h4>Selenium and Rheumatoid Arthritis<\/h4>\n<p>Research shows elevated levels of oxidative stress and reduced levels of blood antioxidants in <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/rheumatoid-arthritis\/symptoms-causes\/syc-20353648\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><em>patients with rheumatoid arthritis.<\/em><\/strong><\/a>\u00a0 Selenium deficiency may be a factor in the development of rheumatoid arthritis.\u00a0 Selenium supplementation alleviates symptoms and reduces inflammation levels in patients with rheumatoid arthritis [Sahebari].<\/p>\n<h4>Selenium and Systemic Lupus Erythematosus (SLE)<\/h4>\n<p>Serum selenium concentrations are <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/lupus\/diagnosis-treatment\/drc-20365790\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>low in patients diagnosed with SLE<\/strong><\/em><\/a>.\u00a0 The precise effect of selenium on SLE patients is not known at present.\u00a0 An animal study has shown that selenium supplementation has significant effects on natural killer cell activity in mice with SLE [Sahebari].<\/p>\n<h4>Selenium and Sj\u00f6gren Syndrome<\/h4>\n<p>Studies have shown that serum selenium levels are low in untreated <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/sjogrens-syndrome\/diagnosis-treatment\/drc-20353221\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>Sj\u00f6gren syndrome patients<\/strong><\/em><\/a>, especially in older patients.\u00a0 One study has shown that supplementation of Sj\u00f6gren syndrome patients with selenium and vitamin E stopped the disease progression in some but not all patients.\u00a0 There is insufficient evidence at present about the effect of selenium on Sj\u00f6gren syndrome patients [Sahebari].<\/p>\n<h4>Selenium and Behcet&#8217;s Disease<\/h4>\n<p>Studies have shown that the serum selenium level in <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/behcets-disease\/diagnosis-treatment\/drc-20351331\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><em>Behcet&#8217;s disease patients<\/em><\/strong><\/a> is much lower than in normal healthy controls.\u00a0 One study has shown that selenium deficiency is associated with impeded immune response in extra-cellular body fluids.\u00a0 However, the exact effect of selenium supplementation of Behcet&#8217;s disease patients is unknown [Sahebari].<\/p>\n<h4>Selenium and Scleroderma (Systemic Sclerosis)<\/h4>\n<p><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/scleroderma\/diagnosis-treatment\/drc-20351957\" target=\"_blank\" rel=\"noopener noreferrer\"><em><strong>Patients with scleroderma<\/strong><\/em><\/a> have generally low selenium levels.\u00a0 One study has shown low levels of the selenium containing antioxidant enzyme glutathione peroxidase in patients with scleroderma.\u00a0 There is a documented correlation between serum selenium concentration and scleroderma disease progression.\u00a0 Selenium supplementation may lessen the extent of the disease progression [Sahebari].<\/p>\n<h4>Conclusion: More Research on Selenium and Autoimmune Diseases is Needed<\/h4>\n<p>More research into the antioxidant and anti-inflammatory effects of selenium supplementation on the initiation of autoimmune diseases and on the clinical improvement of the symptoms of autoimmune diseases is needed.\u00a0 Selenium supplementation may have beneficial effects, especially antioxidant and anti-inflammatory effects, on some autoimmune diseases [Sahebari].<\/p>\n<h3>Sources<\/h3>\n<p>Sahebari, M, Rezaieyazdi, Z &amp; Khodashi, M. (2019).\u00a0 Selenium and autoimmune diseases: a review.\u00a0 Current Rheumatology Reviews, 15: 123-134.<\/p>\n<p>The information contained in this review article is not intended as medical advice and should not be used as such.<\/p>\n<p>15 August 2019<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Selenium is a micronutrient that plays an important role in the oxidative defense of cells and DNA against damage by harmful free radicals.\u00a0 Selenium is the main component of the selenoproteins that play important roles in reproductive function, immune system modulation, and thyroid hormone synthesis [Sahebari]. Low Serum Selenium Levels and Autoimmune Diseases Decreased serum &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/seleniumfacts.com\/index.php\/selenium-autoimmune-diseases\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Selenium and Autoimmune Diseases&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-1374","post","type-post","status-publish","format-standard","hentry","category-inflammation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Selenium and Autoimmune Diseases - Seleniumfacts.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seleniumfacts.com\/index.php\/selenium-autoimmune-diseases\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Selenium and Autoimmune Diseases - Seleniumfacts.com\" \/>\n<meta property=\"og:description\" content=\"Selenium is a micronutrient that plays an important role in the oxidative defense of cells and DNA against damage by harmful free radicals.\u00a0 Selenium is the main component of the selenoproteins that play important roles in reproductive function, immune system modulation, and thyroid hormone synthesis [Sahebari]. 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