{"id":2398,"date":"2021-11-15T11:41:27","date_gmt":"2021-11-15T11:41:27","guid":{"rendered":"https:\/\/seleniumfacts.com\/?p=2398"},"modified":"2021-11-08T10:21:01","modified_gmt":"2021-11-08T10:21:01","slug":"optimal-serum-selenium-status","status":"publish","type":"post","link":"https:\/\/seleniumfacts.com\/index.php\/optimal-serum-selenium-status","title":{"rendered":"Achieving Optimal Plasma Selenium Status"},"content":{"rendered":"

Hurst et al. administered 50-mcg, 100-mcg, or 200-mcg of selenium daily for ten weeks to 119 healthy men and women aged 50\u201364 years living in the United Kingdom.<\/strong><\/p>\n

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A healthy immune system depends upon an optimal selenium status to promote the bio-synthesis of antioxidant selenoproteins.<\/strong><\/figcaption><\/figure>\n

The researchers were testing the effect of the different daily dosages on plasma selenium status and plasma selenoprotein P status. They used a pharmaceutical-grade high-selenium yeast preparation<\/em><\/a> with a documented 88.7% absorption [B\u00fcgel 2004].<\/strong><\/p>\n

The men and women in the study had a daily dietary selenium intake of approximately 55 mcg\/day.\u00a0 Intakes of selenium in the United Kingdom had fallen from a mean of 60 mcg\/day in 1991 to a minimum of 30 to 40 mcg\/day in 1995\u20132000; in 2010, the mean intake was 48\u201358 mcg\/day [Hurst 2010].<\/strong><\/p>\n

Establishing Optimal Selenium Status<\/h5>\n

In the Hurst study, the mean baseline plasma selenium concentration for all participants in the study was 95.7 +\/- 11.5 mcg\/L<\/em><\/strong><\/a>. Ten weeks of daily supplementation led to significantly increased steady-state concentrations as follows:<\/p>\n