{"id":2475,"date":"2021-11-30T12:13:11","date_gmt":"2021-11-30T12:13:11","guid":{"rendered":"https:\/\/seleniumfacts.com\/?p=2475"},"modified":"2021-12-02T13:00:53","modified_gmt":"2021-12-02T13:00:53","slug":"selenium-status-and-mortality-and-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/seleniumfacts.com\/index.php\/selenium-status-and-mortality-and-type-2-diabetes","title":{"rendered":"Selenium Status and Mortality and Type 2 Diabetes"},"content":{"rendered":"

Higher serum selenium concentrations are associated with a statistically significant 31% lower all-cause mortality and a statistically significant 34% lower heart disease mortality in individuals with type-2 diabetes [Qiu 2021].<\/strong><\/p>\n

\"\"This is the conclusion of researchers who conducted a relatively large cohort study of patients with diabetes with a long follow-up period. They analyzed the data from 3199 American adults with type-2 diabetes; the average follow-up period was 12.6 years [Qiu 2021].<\/strong><\/p>\n

During that follow-up period, 1693 deaths were documented, including 425 heart disease deaths [Qiu 2021].<\/strong><\/p>\n

Highest Quartile of Serum Selenium Compared to Lowest Quartile<\/h5>\n

Individuals in the highest quartile of serum selenium concentration had significantly lower all-cause mortality rates and significantly lower heart disease mortality rates when compared with individuals in the lowest quartile of serum selenium concentration<\/em><\/strong><\/a> [Qiu 2021].<\/p>\n

Dose-response Relationship Between Serum Selenium and Mortality<\/h5>\n

Moreover, the researchers observed a linear dose\u2013response relation
\nbetween serum selenium (range: 89\u2013182 mcg\/L) and mortality [Qiu 2021].<\/p>\n

The upper range of serum selenium concentration, up to 182 mcg\/L, is considered a relatively high selenium concentration, but it is still within the
\nnormal physiologic range [Qiu 2021].<\/p>\n

Professor Lutz Schomburg in Berlin explains that higher selenium status may be found in diabetes patients because diabetes seems to cause increased Selenoprotein P (SELENOP ) biosynthesis in the liver and seems to raise the level of circulating SELENOP and selenium<\/em><\/strong><\/a> [Schomburg 2020].<\/p>\n

He explains that, under normal conditions, insulin decreases SELENOP biosynthesis and secretion. In cases of insulin resistance, however, this inhibition declines, causing increased SELENOP levels and higher circulating selenium concentrations [Schomburg 2020].<\/p>\n

Control of Potential Confounding Variables in the Diabetes study<\/h5>\n

In the Qiu study<\/strong><\/em><\/a>, the significantly reduced risks of all-cause death and heart disease death were observed when the researchers stratified the data and adjusted for potential confounding variables [Qiu 2021]:<\/p>\n