{"id":2704,"date":"2022-06-15T06:40:22","date_gmt":"2022-06-15T06:40:22","guid":{"rendered":"https:\/\/seleniumfacts.com\/?p=2704"},"modified":"2022-05-24T07:29:31","modified_gmt":"2022-05-24T07:29:31","slug":"selenium-supplementation-for-senior-citizens","status":"publish","type":"post","link":"https:\/\/seleniumfacts.com\/index.php\/selenium-supplementation-for-senior-citizens","title":{"rendered":"Selenium Supplementation for Senior Citizens"},"content":{"rendered":"<p><strong>Health benefits of daily supplementation of senior citizens with a combination of selenium and Coenzyme Q10:<\/strong><\/p>\n<ul>\n<li><strong>improved heart function as shown on echocardiograms<\/strong><\/li>\n<li><strong>reduced risk of death from heart disease<\/strong><\/li>\n<li><strong>improved health-related quality of life<\/strong><\/li>\n<\/ul>\n<figure id=\"attachment_2540\" aria-describedby=\"caption-attachment-2540\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2540 size-medium\" title=\"Selenium plus Coenzyme Q10 for Senior Citizens\" src=\"https:\/\/seleniumfacts.com\/wp-content\/uploads\/2022\/01\/Alehagen-lecturing-300x225.png\" alt=\"Professor Urban Alehagen\" width=\"300\" height=\"225\" srcset=\"https:\/\/seleniumfacts.com\/wp-content\/uploads\/2022\/01\/Alehagen-lecturing-300x225.png 300w, https:\/\/seleniumfacts.com\/wp-content\/uploads\/2022\/01\/Alehagen-lecturing.png 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-2540\" class=\"wp-caption-text\"><strong>In the KiSel-10 Study, Prof. Urban Alehagen and the research team administered 200 mcg\/day of selenium and 2 x 100 mg\/day of Coenzyme Q10 for 48 months to elderly Swedish citizens whose serum selenium status at baseline was quite low (mean: 67.1 mcg\/L). The duration of the study was 48 months. The benefits of the supplementation were improved heart function and reduced risk of death from heart disease.<\/strong><\/figcaption><\/figure>\n<p><strong>The combined supplementation seems to work by reducing the extent of oxidative stress, systemic inflammation, and fibrosis in the study participants [Alehagen 2022a].<\/strong><\/p>\n<p>Now, data from<a href=\"https:\/\/www.q10facts.com\/coq10-and-selenium-combination\/\" target=\"_blank\" rel=\"noopener\"><strong><em> the KiSel-10 Study<\/em> <\/strong><\/a>show the following effects of the combined supplementation with respect to Fibroblast Growth Factor 23 concentrations in blood:<\/p>\n<ul>\n<li>Supplementation decreased concentrations of FGF-23 hormones.<\/li>\n<li>The study showed a relationship between the circulating level of the FGF-23 and atrial fibrillation.<\/li>\n<li>The study showed an association between the concentration of FGF-23 and death from heart disease.<\/li>\n<li>The study showed an effect of reduced FGF-23 levels on the risk of death from heart disease that is independent of the level of the cardiac wall tension bio-marker NT-proBNP.<\/li>\n<li>There exists a close interrelationship between FGF-23 concentrations and kidney function.<\/li>\n<\/ul>\n<h5>Why are FGF-23 Concentrations Important?<\/h5>\n<p>Prof. Alehagen explains that FGF-23 is a hormone that is secreted into the blood circulation. One of its primary functions is the regulation of the vitamin D metabolism and of the phosphorous metabolism in the kidneys.<\/p>\n<p>However, there seems to be <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8834214\/\" target=\"_blank\" rel=\"noopener\"><em><strong>an association between FGF-23 activity and cardiovascular mortality<\/strong><\/em><\/a> even in the absence of kidney disease. Experimental data show that FGF-23 may act as a mediator for cardiac hypertrophy, cardiac fibrosis, and cardiac dysfunction [Alehagen 2022b].<\/p>\n<h5>Mechanisms of the FGF-23 Effect on the Risk of Cardiovascular Disease<\/h5>\n<p>Prof. Alehagen writes that the exact biological mechanisms of the influence of FGF-23 on the cardiovascular system are not clearly known.<\/p>\n<p>Possible explanations of an effect on cardiovascular disease include the following:<\/p>\n<ul>\n<li>relationship between FGF-23 and inflammation<\/li>\n<li>influence of FGF-23 on vitamin D activity<\/li>\n<\/ul>\n<h5>Conclusion: Selenium and CoQ10 important as we age<\/h5>\n<p>Prof. Urban Alehagen and a team of researchers concluded that the <a href=\"https:\/\/www.healthandscience.eu\/index.php?option=com_content&amp;view=article&amp;id=864:supplementation-with-q10-and-selenium-halves-your-cardiovascular-risk-for-numerous-years-us&amp;lang=us&amp;tmpl=component&amp;Itemid=374\" target=\"_blank\" rel=\"noopener\"><em><strong>administration of selenium and Coenzyme Q10 to elderly community-living citizens low in both substances 1) prevented an ageing-related increase in FGF-23 and 2) reduced cardiovascular disease risk<\/strong><\/em><\/a> [Alehagen 2022b].<\/p>\n<p>Fibroblast growth factor 23 is a hormone that has an important relationship with cardiovascular function and the risk of cardiovascular disease.<\/p>\n<p>The <a href=\"https:\/\/www.q10facts.com\/the-kisel-10-study\/\" target=\"_blank\" rel=\"noopener\"><strong><em>combined supplementation with selenium and Coenzyme Q10 has been shown to have positive effects on systemic inflammation, oxidative stress, fibrosis, endothelial function, and renal function in elderly citizens low in<\/em><\/strong><\/a><br \/>\n<strong><em>selenium and Coenzyme Q10.<\/em><\/strong><\/p>\n<h5>Sources<\/h5>\n<p>Alehagen U, Johansson P, Svensson E, Aaseth J, Alexander J. Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden. Eur J Nutr. 2022a;10.1007\/s00394-022-02876-1.<\/p>\n<p>Alehagen U, Aaseth J, Larsson A, Alexander J. Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10 in an Elderly Swedish Population: A Sub-Analysis. Cells. 2022b;11(3):509.<\/p>\n<p>The information contained in this review article is not intended as medical advice and should not be used as such.<\/p>\n<p>15 June 2022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Health benefits of daily supplementation of senior citizens with a combination of selenium and Coenzyme Q10: improved heart function as shown on echocardiograms reduced risk of death from heart disease improved health-related quality of life The combined supplementation seems to work by reducing the extent of oxidative stress, systemic inflammation, and fibrosis in the study &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/seleniumfacts.com\/index.php\/selenium-supplementation-for-senior-citizens\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Selenium Supplementation for Senior Citizens&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[60,50,106,59,107,35],"class_list":["post-2704","post","type-post","status-publish","format-standard","hentry","category-cardiovascular-disease","tag-cardiovascular-disease","tag-coenzyme-q10","tag-fibroblast-growth-factor","tag-heart-disease","tag-heart-function","tag-selenium"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Selenium and Coenzyme Q10 combine to low inflammation and stress<\/title>\n<meta name=\"description\" content=\"Combined supplementation of elderly citizens with selenium and Coenzyme Q10 lower levels of inflammation and preserve renal function\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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