{"id":3686,"date":"2025-04-30T08:50:42","date_gmt":"2025-04-30T08:50:42","guid":{"rendered":"https:\/\/seleniumfacts.com\/?p=3686"},"modified":"2025-04-02T14:15:14","modified_gmt":"2025-04-02T14:15:14","slug":"selenium-and-thyroid-function","status":"publish","type":"post","link":"https:\/\/seleniumfacts.com\/index.php\/selenium-and-thyroid-function","title":{"rendered":"Selenium and Thyroid Function"},"content":{"rendered":"

Data from a 2025 KiSel-10 sub-study analysis suggest that serum CD5L levels may be an additional biomarker for improved thyroid function. Serum CD5L levels may also be a suitable biomarker for adequate selenium status and for reduced mortality risk.<\/strong><\/p>\n

\"Illustration
Adequate selenium intake is necessary for good thyroid function. Selenium is a component of the deiodinase enzymes that help convert inactive T4 thyroid hormone to active T3 thyroid hormone. Some selenoproteins act as antioxidants to protect the thyroid against oxidative damage. Selenium may help reduce the risk of autoimmune thyroid disorders.<\/strong><\/figcaption><\/figure>\n

Combined supplementation of elderly citizens with selenium and Coenzyme Q10 for 48 months significantly increased the level of circulating CD5L. The supplementation was associated with improved health-related quality of life and improved survival odds. Meanwhile, in the study\u2019s placebo group, significantly higher cardiovascular mortality within 10 years was associated with low levels of circulating CD5L. The combined selenium and Coenzyme Q10 supplementation reduced the mortality risk. The active treatment in the KiSel-10 clinical trial was 200 mcg of selenium from selenium-enriched yeast and two times 100 mg of ubiquinone Coenzyme Q10 daily [Alehagen 2025].<\/strong><\/p>\n

The full name for CD5L is Cluster of Differentiation 5. CD5L is a protein that supports numerous activities in the body. Tissue-resident macrophages produce CD5L proteins. Low CD5L levels have been associated with clinical conditions such as atherosclerosis and inflammation [Alehagen 2025].<\/p>\n

Selenium and Thyroid Hormones<\/h5>\n

In this 2025 sub-study, Prof Alehagen et al analyzed CD5L levels in serum<\/a> samples from 359 KiSel-10 study participants at baseline and after 48 months of intervention. The combined selenium and Coenzyme Q10 supplementation significantly increased the serum levels of CD5L and free thyroid hormone T3. These outcomes indicate that CD5L positively responds to combined selenium and Coenzyme Q10 supplementation. Accordingly, CD5L levels correlate with improved thyroid hormone status and with positive health-related quality of life indices [Alehagen 2025].<\/p>\n

In a 2024 sub-study, Prof Alehagen et al reported that combined supplementation with selenium and Coenzyme Q10 for four years had the following beneficial effects on thyroid function<\/a> [Alehagen 2024]:<\/p>\n