There are clear differences in the metabolic profiles of elderly men who took 200 micrograms of selenium and 2 x 100 milligrams of Coenzyme Q10 daily for at least 18 months as compared with the metabolic profiles of elderly men who took matching placebos [Alehagen 2019].
Drawing on data from a sub-analysis of the KiSel-10 Study, Professor Urban Alehagen reported that the major differences were seen primarily in the following biological pathways [Alehagen 2019]:
- pentose phosphate pathway (the pathway for the generation of nicotinamide adenine dinucleotide phosphate, which is a substance that reduces ubiquinone Coenzyme Q10)
- mevalonate pathway (the pathway for the synthesis of cholesterol, Coenzyme Q10, and dolichol)
- beta-oxidation pathway (the pathway for the breaking down of fatty acid molecules to produce energy and to produce acetyl-CoA, FADH2 and NADH, which are needed for the citric acid cycle [Krebs cycle]
There were other significant metabolic changes associated with the selenium and Coenzyme Q10 supplementation of senior citizens as well [Alehagen 2019].
Changes in Metabolic Profile After Supplementation with Selenium and Coenzyme Q10
In this study, Professor Alehagen and his team of researchers analyzed the metabolic patterns of 95 metabolites in the plasma of elderly men.