Pregnancy Archives - Seleniumfacts.com

March 30, 2022March 28, 2022

Selenium Supplementation and Preeclampsia Risk

Selenium supplementation of pregnant women at a high risk of preeclampsia has shown beneficial effects on 1) serum selenium levels, 2) some metabolic profiles, 3) uterine artery pulsatility index, and 4) mental health, compared to placebo. The study compared the effect in 60 pregnant women of supplementation with 200 mcg/day for 12 weeks with the effect of placebo for the same period.

Pregnant woman — Preeclampsia is a serious hypertensive condition of pregnancy. It is associated with high risk of maternal and fetal morbidity and mortality. Selenium intake and status have been linked to the occurrence of preeclampsia.

The supplementation took place for 12 weeks starting in weeks 16 to 18 of pregnancy. No side effects related to the intake of 200 mcg of selenium per day by pregnant women at high risk of preeclampsia were reported throughout the duration of the study [Mesdaghinia 2022].

Selenium Supplementation Compared to Placebo

How did the selenium supplementation compare with the placebo supplementation in the pregnant women? read more

December 15, 2020January 22, 2021

Low Selenium Status and At-Risk Pregnancies

A recent review article presents the evidence that low selenium status in pregnant women may be implicated in the following complications [Duntas 2020]:

miscarriage
preeclampsia
pre-term birth
retarded fetus intrauterine growth
post-partum hypothyroidism and auto-immune thyroiditis

To ensure an optimal pregnancy outcome, Dr. Leonidas Duntas recommends that physicians take an individualized approach and prescribe dietary and supplemental selenium intakes that are tailored to the pregnant woman’s needs.

Why is Adequate Selenium Important for Pregnant Women?

Selenium is an essential trace element. Its intake and status in the blood plasma can vary considerably according to a number of factors [Duntas 2020]:

differences in diet and nutrition
differences in soil and plant selenium content
ethnic differences
genetic differences

Without a blood selenium test, it is not possible to know whether women planning a pregnancy have sufficient circulating selenium. The Mayo Clinic reports that the normal selenium concentration in adult human blood serum in the United States is 70 to 150 micrograms per liter with a population mean value of 98 micrograms per liter. read more

July 1, 2019July 1, 2019

Selenium Supplementation and Polycystic Ovary Syndrome (PCOS)

Polycystic ovary syndrome (PCOS) occurs in 5 to 10% of women. It is the most common cause of infertility in women. PCOS is typically described by the presence of common symptoms: mild obesity, irregular periods or absence of a period, and signs of excessive androgen such hirsutism and acne. Most PCOS patients will have multiple cysts in the ovaries. More research into the effects of selenium supplementation on PCOS is needed.

Polycystic ovary syndrome (abbreviated PCOS) is a hormonal disorder with a prevalence of 5 – 10% in women of reproductive age.

The exact cause of PCOS is unknown.
Symptoms of PCOS include irregular periods, increased levels of male hormone, and failure of the ovaries to function regularly.
Excess insulin production and low-grade inflammation are thought to have an effect on the development of PCOS [Mayo Clinic].

Selenium: Effect on Mental Health, Hormonal Profile, Inflammation, and Oxidative Stress in Patients with PCOS

In a randomized controlled trial enrolling 60 women aged 18 – 40 years, daily co-administration of a probiotic supplement and 200 micrograms of selenium for 12 weeks was associated with the following outcomes [Jamilian 2018]:

significant improvement in Beck Depression Inventory scores, general health questionnaire scores, and depression anxiety and stress scale scores compared with the placebo
significantly reduced total testosterone levels, hirsutism, high-sensitivity C-reactive protein levels (a bio-marker for inflammation), and malondialdehyde levels (a bio-marker for oxidative stress) as well as significantly increased total antioxidant capacity and total glutathione (GSH) levels compared with the placebo

The researchers concluded that the co-administration of probiotics and selenium for 12 weeks to women with PCOS had beneficial health effects.

Selenium: Effect on Metabolic Profile in Patients with PCOS

In a randomized controlled trial enrolling 70 women aged 18 – 40 years, daily supplementation with 200 micrograms of selenium for 8 weeks was associated with the following outcomes compared with placebo [Jamilian 2015]: read more

Milestones in early selenium research

1817 Swedish chemist Jöns Jakob Berzelius discovers selenium

1957 Biochemist Klaus Schwarz shows that selenium in microscopic amounts has a vital importance for mammalian health

1969 Professor J.T. Rotruck discovers that selenium has a biochemical role as a component of the antioxidant enzyme glutathione peroxidase

1969 Professors R.J. Shamberger and D.V. Frost report a possible protective effect of selenium against cancer in humans

1973 Professor J.T. Rotruck identifies the enzyme glutathione peroxidase as a selenium-dependent protein

1977 Professor G.N. Schrauzer publishes cancer mortality correlation studies showing an inverse correlation between dietary intakes of selenium and cancer mortality in 27 countries

1988 Professor G.Q Yang summarizes the lessons learned about the selenium-related endemic diseases Keshan disease and Kashin-Beck disease and about the importance of adequate daily selenium intakes

1989 Professor G.G. Duthie publishes evidence for a role of selenium in the prevention of cardiovascular disease

1993 Researcher W.J. Blot publishes the results of the Nutrition Intervention Trials in Linxian, China, showing that supplementation with a combination of selenium and other antioxidants reduces the risk of cancer

1994 Professor G.N. Schrauzer publishes evidence that selenium is important in the maintenance and therapy of HIV-infected patients

1996 Professor Larry Clark publishes the results of a randomized controlled trial – the Nutritional Prevention of Cancer study -- that shows selenium's cancer-protective effects on colon cancer, lung cancer, and prostate cancer

1997 Professor G.F. Combs summarizes the evidence for the protective effects of selenium against cancer

1999 Professor J.E. Oldfield publishes his Selenium World Atlas, mapping areas of selenium deficiency around the world

2000 Researcher O.A. Levander publishes evidence showing an anti-viral effect of selenium

2002 Researcher R. Gärtner shows that supplementation with selenium reduces inflammation in patients with autoimmune thyroiditis

2002 Researcher Margaret Rayman presents the arguments for increasing selenium intakes to realize selenium’s antioxidant and anti-viral and anti-inflammatory effects as well as selenium’s enhancement of immune function and reproductive success.