Selenium Status and Mortality and Type 2 Diabetes

Higher serum selenium concentrations are associated with a statistically significant 31% lower all-cause mortality and a statistically significant 34% lower heart disease mortality in individuals with type-2 diabetes [Qiu 2021].

This is the conclusion of researchers who conducted a relatively large cohort study of patients with diabetes with a long follow-up period. They analyzed the data from 3199 American adults with type-2 diabetes; the average follow-up period was 12.6 years [Qiu 2021].

During that follow-up period, 1693 deaths were documented, including 425 heart disease deaths [Qiu 2021].

Highest Quartile of Serum Selenium Compared to Lowest Quartile

Individuals in the highest quartile of serum selenium concentration had significantly lower all-cause mortality rates and significantly lower heart disease mortality rates when compared with individuals in the lowest quartile of serum selenium concentration [Qiu 2021]. read more

Achieving Optimal Plasma Selenium Status

Hurst et al. administered 50-mcg, 100-mcg, or 200-mcg of selenium daily for ten weeks to 119 healthy men and women aged 50–64 years living in the United Kingdom.

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A healthy immune system depends upon an optimal selenium status to promote the bio-synthesis of antioxidant selenoproteins.

The researchers were testing the effect of the different daily dosages on plasma selenium status and plasma selenoprotein P status. They used a pharmaceutical-grade high-selenium yeast preparation with a documented 88.7% absorption [Bügel 2004].

The men and women in the study had a daily dietary selenium intake of approximately 55 mcg/day.  Intakes of selenium in the United Kingdom had fallen from a mean of 60 mcg/day in 1991 to a minimum of 30 to 40 mcg/day in 1995–2000; in 2010, the mean intake was 48–58 mcg/day [Hurst 2010]. read more