Plasma Selenoprotein P Levels and the Risk of Cardiovascular Disease

Research conclusion: “The 20% with lowest SELENOP concentrations in a N orth European population without history of cardiovascular disease have markedly increased risk of cardiovascular morbidity and mortality” [Schomburg 2019].

Heart attack
Selenoprotein-P deficiency predicts cardiovascular disease and death. Low selenium intakes result in sub-optimal bio-synthesis of selenoprotein P in the liver. Now, research shows that low selenoprotein P concentrations are associated with increased risk of cardiovascular disease and mortality.

This is the conclusion from the Malmö Preventive Project, a population-based prospective cohort study in southern Sweden, that examined the relationship between plasma selenoprotein P status and 1) risk of all-cause mortality, 2) risk of cardiovascular mortality, and 3) risk of a first cardiovascular event in 4366 study participants.

Note that this was a study done with study participants who had no history of cardiovascular disease. It was truly a study of the relationship between selenium status and the risk of heart disease. read more

Selenium Supplementation and Anti-Ageing Effects

The development of ageing-related diseases seems to be closely related to the extent of damage inflicted on the cells by oxidative stress. Researchers define oxidative stress as damage to proteins, nucleic acids, and lipids caused by an imbalance between harmful reactive oxygen species (frequently referred to as free radicals) and the body’s antioxidative defenses [Alehagen 2021].

Elderly couple on the beach
We want to stay as young as possible as late in life as possible. Ensuring that we have an optimal intake of selenium is associated with protection against several aspects of ageing.

A 2021 review of the relevant research literature reveals the following findings [Alehagen 2021]:

-Optimal selenium status is necessary for the synthesis of the antioxidant seleno-enzymes: the glutathione peroxidases and the thioredoxin reductases.

-Selenium deficiency in elderly individuals seems to increase the risk of developing age-related diseases: chronic inflammation, cardiovascular disease,  cancer, and neurodegenerative diseases. read more