Here are the main points from a recent review article on the topic of aging and exposure to heavy metals and kidney function:
The efficiency with which the kidneys remove waste and excess fluid from the blood declines with age in individuals who are older than 50–60 years.
Exposure to metal pollutants may be detrimental to the kidneys of normal healthy adults and exacerbates the functional decline of the kidneys in seniors. Given the prevalence of these heavy metal toxicants in the environment, it is nearly impossible for people to avoid exposure.
Studies have shown that exposure to mercury, cadmium, and/or lead is associated with an increase in the incidence and the severity of kidney disease in elderly individuals. There is some reason to think that adequate selenium status helps to protect against the damage of heavy metal toxicants.
Unfortunately, the early signs of kidney dysfunction often go unnoticed.
Mercury, Cadmium, Lead – Difficult to Avoid
Prof. Aaseth et al. write that toxic metals are so abundant in the environment that it is almost impossible for humans to avoid contact with them.read more
Fish should be an important part of our diets. Professor Nick Ralston at the University of North Dakota has drawn our attention to the webpages entitled Fish, Mercury, and Nutrition: The Net Effects. The URL is http://net-effects.und.edu/factsheets.aspx
On these webpages, Professor Ralston and his colleagues explain why the benefits of regularly eating fish, especially ocean fish, are often overlooked. Too many of us have cut back on our fish consumption because we have been worried about exposure to toxic mercury.
However, we have been receiving insufficient information about the relative benefits and risks of eating ocean fish. In fact, our avoiding fish meals may be having negative health consequences in some cases.read more
The selenium in our cells is the molecular “target” of toxic mercury. Inhibition of the normal biological activity of seleno-enzymes is the mechanism by which mercury damages our cells, most particularly our brain and nerve cells [Ralston & Raymond 2018].
Conceiving of selenium as the “target” of mercury leads to a better understanding of mercury toxicity than the old theory of selenium as the “tonic” that binds toxic mercury in a form that is no longer harmful [Ralston & Raymond 2018].
Professor Nicholas Ralston and consultant Lisa Raymond have done a review of the research literature about the characteristics of mercury toxicity to identify the selenium-dependent aspects of mercury’s biochemical mechanisms and effects. Their conclusions [Ralston & Raymond 2018]:read more
The research evidence to date suggests that there is a U-shaped relationship between selenium intake and health. According to a recent report by the long-time selenium researcher Professor Dr. Margaret P. Rayman, University of Surrey, UK, both selenium deficiency and selenium excess have been associated with adverse health effects.
Conditions Indicating a Need for Selenium Supplementation
Professor Rayman lists a number of conditions that have been associated in the research literature with selenium deficiency:
Keshan disease (a heart muscle disease caused by a selenium deficiency together with a strain of Coxsackie virus)
Kashin-Beck disease (a bone disease for which selenium deficiency is a factor)
She does mention a US National Health and Nutrition Examination Survey that measured the serum selenium levels in 13,887 adult participants and then followed up for mortality for up to 18 years. The mortality in that study showed a U-shaped association between serum selenium and death, with a serum selenium concentration of 135 micrograms per liter at the bottom of the U [Rayman 2019].read more
Selenium containing antioxidant selenoproteins play an important role in the prevention and reversal of oxidative damage in the brain. This role has generally been underestimated in studies of the toxicity of elemental mercury and methylmercury. The common understanding has been that selenium helps to prevent mercury toxicity by binding with mercury and rendering the mercury inactive.
This chemical binding and inactivation of mercury does take place. Mercury has a great affinity for selenium, estimated to be approximately one million times stronger than mercury’s affinity for sulfur. So, selenium’s binding with mercury in the tissues does keep the mercury from getting into mischief in the brain and spinal cord, peripheral nervous system, and endocrine system.read more
Too many of us are missing out on the health benefits of the omega-3 fatty acids available to us from eating certain types of fish a couple of times a week. Why are we avoiding fish? Because many of us are afraid of “eating mercury” in the fish.
It turns out, there is research to show that this is a misconception. Professor Nick Ralston and his colleagues at the University of North Dakota’s Energy and Environmental Research Center have measured and evaluated the molar ratios of selenium in fish to the mercury in fish [Ralston 2007, 2016].
Their studies show that many of the edible ocean fish have an abundance of selenium in relation to mercury. So, not only are we missing out on the omega-3 fatty acid benefits, we are also missing out on a good source of dietary selenium [Berry 2008].read more
Early exposure to natural elements that are toxic – cadmium, mercury, and lead – can have long-term adverse health consequences. Children exposed to these elements while still in the uterus and while breast-feeding may suffer lasting damage to the brain and nervous system and to the kidneys and liver. The question is: to what extent can selenium supplementation reduce the risk of toxic damage?
Given the dangerous nature of these poisonous heavy metals – cadmium, mercury, and lead – both for the mother and for the fetus and the neonate, it is difficult to carry out randomized controlled studies. Instead, the best evidence we have for the beneficial effects of selenium supplementation comes from studies that relate the degree of exposure and the selenium status of the mother and the child.read more
Mercury. In the form of methylmercury, it is a very harmful biological toxin. It is a threat to our brains and nervous systems and our livers and our kidneys. Too much exposure to methylmercury is likely to cause brain damage and nerve damage.
Fortunately, selenium supplements can help. And they do help. The relationship of mercury and selenium is a story with an ironic twist. To the extent that selenium binds with mercury in the body and de-toxifies the mercury – a very good thing for us – to that extent the body is robbed of selenium that could be used for the production of beneficial selenoproteins with other important biological functions.
Protecting us against the toxic effects of mercury means fewer selenoproteins to act as antioxidants neutralizing harmful free radicals, fewer selenoproteins to strengthen immune system function and thyroid function, and fewer selenoproteins to help reduce the risk of cancer.read more
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