Selenium Protects Against Methylmercury in Fish

The health benefits of eating fish outweigh the health risks. This is especially true when we have sufficient dietary selenium intake and sufficient selenium status to 1) give a protective effect against methylmercury and 2) serve other biological purposes [Jorge 2024].

Salmon dinner contains selenium
Fatty fish such as herring, mackerel, and salmon are especially good sources of omega-3 fatty acids, protein, selenium, and vitamin D. Eating fatty fish regularly may reduce the risk of heart disease and stroke and enhance brain health.

To varying degrees, all fish contain some mercury. The mercury in fish and seafood is primarily in the form of methylmercury. Unchecked, the methylmercury targets the nervous system. It disrupts cellular processes. Too much exposure can lead to a loss of muscular coordination and to a loss in cognitive function. Accordingly, the presence of mercury could be a health risk for people who eat fish regularly [Jorge 2024].

Fortunately, many edible fish contain selenium in molar concentrations adequate to sequester the methylmercury in the fish and to render it less harmful. Ralston & Raymond have developed criteria for the calculation of selenium health based values. The calculations are based on the relative molar concentrations of mercury and selenium in various types of fish [Ralston 2016]. read more

Selenium and Type 2 Diabetes

Selenium supplementation and the possible risk of developing type 2 diabetes, what do we know? This is a complex issue. Many different biological, hormonal, and environmental factors have an effect on the relationship.

Selenium and diabetes interrelationship
Observational evidence points to relevant sex differences in the selenium-diabetes interrelationship. There may be potential harmful effects in men living in selenium-rich areas and in men with high habitual selenium intake. Research shows potential benefits of selenium on diabetes risk in women selenium-deficient areas or in women with low selenium intake.

In a 2024 review, Demircan and a selenium research team headed by Prof Lutz Schomburg, Charité Berlin, investigated the current evidence for a relationship between selenium and type 2 diabetes. Recent evidence points to selenium intake and serum selenium status as relevant factors in the study of type 2 diabetes complications and prognosis.

Two studies based on data from the National Health and Nutrition Examination Survey (NHANES) in the United States have identified selenium intake and serum selenium status, respectively, as associated with the improved survival of type 2 diabetes patients [Demircan 2024]. read more