China and Corona Virus will be forever linked in our minds. However, there is another important connection that we should be making: selenium status and its effect on COVID-19 virus in China.
Let me explain. Chinese and American and British researchers have published a letter in the American Journal of Clinical Nutrition in which they report evidence of a significant association between regional selenium status and the reported cure-rate of COVID-19 infected patients in China [Zhang 2020].
Beginning in mid-February 2020, the researchers collected data from the Baidu website, which they describe as a non-governmental website that provides daily updates of reports from the health commission of each province in China.read more
Viruses and viral infections are scary enough in and of themselves. Witness the effects of the current corona virus pandemic COVID-19.
Even more scary are the effects of nutritional deficiencies such as selenium deficiency on the body’s ability to fight off a viral infection.
Selenium Deficiency Associated with Increased Virulence of Viruses
Low selenium status, defined variously as serum selenium status below 70 micrograms per liter or below 85 micrograms per liter, is associated with the following deleterious effects of viral contagion [Méplan & Hughes 2020]:
The viral pathogens induce oxidative stress by generating more harmful free radicals. The result is oxidative damage to cells, proteins, and DNA.
The viral pathogens diminish the cells’ antioxidant defenses including diminishing the activity of the antioxidant seleno-enzymes, e.g. the glutathione peroxidases and the thioredoxin reductases.
The viral pathogens increase oxidative stress to the extent that it can induce mutations of the genomes of the attacking virus. The result is that the mutated viruses are more virulent than the initial viruses were. This increased virulence of mutated viruses has been seen in both coxsackie viruses and influenza viruses. The consequence of the increased virulence is to make the viruses more dangerous even to people with adequate selenium status.
The viral pathogens reduce the ability of the immune system to respond to the virus. This reduced immune response to viruses has also been seen in the response of selenium deficient humans to the HIV virus and the hepatitis B and C viruses.
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