Selenium Supplementation and Preeclampsia Risk

Selenium supplementation of pregnant women at a high risk of preeclampsia has shown beneficial effects on 1) serum selenium levels, 2) some metabolic profiles, 3) uterine artery pulsatility index, and 4) mental health, compared to placebo. The study compared the effect in 60 pregnant women of supplementation with 200 mcg/day for 12 weeks with the effect of placebo for the same period.

Pregnant woman
Preeclampsia is a serious hypertensive condition of pregnancy. It is associated with high risk of maternal and fetal morbidity and mortality. Selenium intake and status have been linked to the occurrence of preeclampsia.

The supplementation took place for 12 weeks starting in weeks 16 to 18 of pregnancy. No side effects related to the intake of 200 mcg of selenium per day by pregnant women at high risk of preeclampsia were reported throughout the duration of the study  [Mesdaghinia 2022].

Selenium Supplementation Compared to Placebo

How did the selenium supplementation compare with the placebo supplementation in the pregnant women? read more

Selenium Deficiency and Heart Failure

Heart failure – the inability of the heart muscle to pump a sufficient quantity of blood out to the body – is a debilitating disease, resulting in shortness of breath, congestion in the lungs, and pooling of blood in the lower extremities. Heart failure is equivalent to diminished quality of life.

Depiction of a mitochondrion. The mitochondria in our cells convert energy sources such as fatty acids, glucose, and ketones into ATP energy molecules. Sufficient intakes of micronutrients such as selenium, Coenzyme Q10, and zinc are important for mitochondrial energy production and for antioxidant protection of cells, lipids, proteins, and DNA.

The prognosis for heart failure is poor, and the available medical therapies for patients with heart failure are inadequate. New treatment strategies are needed [Mortensen 2015].

Yin et al have analyzed the data from 39,757 adults in a cross-sectional study from the 2005–2018 US National Health and Nutrition Examination Survey. Their findings suggest that high levels of combined dietary antioxidant micronutrients are associated with decreased prevalence of various forms of cardiovascular disease and that selenium has the greatest contribution to this association [Yin 2022]. read more