IV Selenium Supplementation for Critically Ill Patients

Critically ill patient
Increased generation of harmful free radicals and increased systemic inflammation seem to play a direct role in cell death, increased morbidity, and higher mortality in critically ill patients. Selenium is a trace element that has cell regulatory, immunologic, and antioxidant and anti-inflammatory functions. Early selenium supplementation is a promising adjunctive therapy for critically ill patients.

Selenium supplementation – especially intravenous selenium supplementation – seems to be a promising adjuvant treatment for critically ill patients.

The aggregated results of a meta-analysis of the clinical outcomes of selenium supplementation on critically ill patients shows that intravenous selenium supplements as a single therapy can decrease the total mortality and can shorten the length of stay in hospital [Zhao 2019].

Furthermore, the results from the meta-analysis showed that the selenium supplementation did not increase the incidence of drug-induced side effects compared with the control group [Zhao 2019].

Selenium Supplementation for Critically Ill Patients – The Evidence

The researchers reviewed 19 randomized controlled trials enrolling 3341 critically ill patients. There were 1694 critically ill patients in the selenium supplementation group and 1647 critically ill patients in the control group. read more

Selenium Supplementation and HIV Infections: A Review

Symptoms of AIDS
The six selenium and HIV infection studies show a beneficial effect of daily supplementation with 200 micrograms of selenium on immune function, in particular on CD4 white blood cell counts. The same beneficial effect on the immune system may be protective against other forms of infection, including against Covid-19 infections.

Six randomized controlled studies show that providing daily selenium supplementation to HIV-infected adults increases CD4 cell counts, reduces the risk of diarrhea morbidity, and lowers hospital admission rates for HIV-related conditions and opportunistic infection in HIV-infected adults [Kayode 2020].

Alexander et al [2020] have recognized the importance of selenium to immune system function and have recommended the initiation of adequate selenium supplementation in high-risk Covid-19 areas and as soon as possible after a suspected Covid-19 infection.

Richie et al [2014] have shown that selenium supplementation in the form of selenium-enriched yeast provides significantly greater protection against oxidative stress than supplementation with exclusively selenomethionine does. read more