Selenium Supplementation and Alzheimer’s Disease

Clinical studies show a clear correlation between Alzheimer’s Disease and low selenium status.  Lower selenium status is associated with worse cognitive decline [Aaseth 2016].

In many regions of Europe and the Middle East, there is poor selenium content in the soil and, accordingly, lower intake of selenium from food sources [Stoffaneller & Morse 2015; Winther 2020].

Woman with Alzheimer's
Adequate levels of selenium are essential for brain function; in fact, the brain is one of the organs that is supplied with selenium at the expense of other organs and tissues in times of low selenium intake. Selenoprotein P plays a special role in delivering selenium to the brain and the neurons. Some of the glutathione peroxidase and thioredoxin reductase selenoenzymes are important intracellular antioxidants in neurons and glia cells of the central nervous system.

The daily intake of selenium from food in many European countries is well below the amount needed for optimal function of important selenoproteins. The needed intake of selenium from food is  estimated to be at least 105 mcg per day [Winther 2020, fig. 2].

Using evidence from human studies in various countries, Prof. Jan Aaseth and colleagues have documented the association between lower selenium  status and Alzheimer’s Disease and/or cognitive impairment [Aaseth 2016]. read more

Adjuvant Treatment of Graves’ Hyperthyroidism with Selenium Yeast

Thyroid disease. Hyperthyroidism. Adjuvant treatment of thyroid disease with selenium yeast supplementation. All topics of interest. At this writing (August 2022), we await the publication of the outcomes of the GRASS clinical trial. GRASS is the acronym for the selenium supplementation for patients with Graves’ hyperthyroidism study [study protocol described by Watt 2013].

What is Graves’ Hyperthyroidism?

Thyroid gland
The thyroid gland is a butterfly-shaped endocrine gland in the neck below the Adam’s apple that makes and stores hormones that help regulate blood pressure, body temperature, heart rate, and the rate at which food is converted into energy. [This image is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.]
Hyperthyroidism is an autoimmune disease. It causes overactivity of the thyroid gland, resulting in too much production of the hormone thyroxine. Hyperthyroidism can cause an acceleration of the body’s metabolism; it can cause weight loss and rapid or irregular heartbeat.

Hyperthyroidism is caused by a number of conditions, including Graves’ disease, which is a common cause. Graves’ disease is the result of immune system disorder. It can affect anyone, but it is more common in women and in individuals under the age of 40. read more