Seleniumfacts.com

December 12, 2016December 22, 2016

Selenium and colorectal cancer: The Bonelli study

Dr. Luigina Bonelli and a team of researchers in Genoa, Italy, were motivated by the following set of compelling facts:

Colorectal cancer was the second leading cause of cancer death in Europe.
Adenomas in the colon (adenomas are benign tumors, which sometimes transform to malignant tumors) were known to be precursors of colorectal cancer.
Patients who had undergone a colonic polypectomy (removal of an adenomatous polyp) had an increased risk of developing colorectal cancer and needed to have periodic follow-up colonoscopies.
Increased risk of developing adenomas was equated with increased risk of developing colorectal cancers.
Observational studies indicated that there was an association between the plasma or serum concentrations of several antioxidant substances including selenium and the risk of colorectal cancer.
In some intervention studies, supplementation with selenium was associated with reductions in the incidence of colorectal cancer.

The time was right to start a large study of the effectiveness of selenium and other antioxidants in reducing the risk of colorectal cancer.

Selenium to reduce the risk of colorectal cancer
Dr. Bonelli and her colleagues wanted to see if daily supplementation with a combination of antioxidants including selenium could reduce the risk of recurrent adenomas in patients who had had one or more adenomatous polyps removed. The researchers designed a randomized, double-blind, placebo-controlled clinical trial and, over the period of many years, they enrolled a total of 411 patients who had undergone a polypectomy. read more

November 30, 2016January 16, 2017

How we know that selenium supplementation is important

Selen supplementation, virus — Adequate intakes of selenium are needed to ensure the optimal functioning of the selenoproteins in the body. Selenoproteins provide protection against the development of cancer and heart disease; they are important for immune system defense; they protect against damage caused by heavy metals and chemical toxins and radiation. And, there is evidence that some of the selenoproteins have anti-viral properties.

Selenium? A trace element? You might well ask: How do we know that adequate amounts of dietary and supplemental selenium are important to us?
The first answer is: because we can see that selenium deficiency makes people sick.
A further answer is that we now know that selenium is an essential component of antioxidant enzymes.
And, on the basis of the results of randomized controlled trials, we know that selenium supplementation reduces the risk of cancer, reduces the risk of heart disease, and improves immune function.
Selenium is also very useful for reducing the toxic effects of heavy metals in the body.

Reason number one: Selenium-deficiency diseases
Keshan disease
In the 1960’s and 1970’s, thousands of people living in a region of China with selenium-poor soil, and, consequently, with selenium-poor food, died from the effects of a form of heart disease. The disease, which took its name from Keshan county in the afflicted region of China, is characterized by inflammation and enlargement of the heart muscle and excess fluid in the lungs. The primary cause of the disease was selenium deficiency. read more

November 26, 2016December 22, 2016

Dr. Gerhard N. Schrauzer – renowned selenium researcher

Dr. Gerhard N. Schrauzer was the grand old man of selenium science. Actually, he was the grand old man of trace element research in the United States for 30 years or more. He was one of the pioneers and one of the major figures in selenium research. Let’s take a look at the useful contributions of information to the selenium supplementation knowledge base that Dr. Schrauzer made.

First, who was Dr. Schrauzer in the context of selenium research?
Dr. Schrauzer did his graduate study in chemistry at the University in Munich, Germany. He was awarded his Ph.D. summa cum laude. From 1966 to 1994, he was a chemistry and biochemistry professor at the University of California in San Diego (UCSD). After his retirement, he was a professor emeritus at UCSD. read more

November 18, 2016January 16, 2017

The functions of selenium supplements

skin-cells antioxidant — Selenium is an important component of the antioxidant defense in the cells. It helps to protect against oxidative damage to both cells and DNA. It has been shown to have a protective effect against the damage to skin cells caused by ultraviolet radiation.

Why the interest in selenium facts? Here, at the beginning of the seleniumfacts.com website, we want to review in broad terms what we know about the functions of selenium supplementation. We are especially interested in selenium’s antioxidant and anti-inflammatory effects in the human body.

Selenium is an essential trace element in the human diet, and, in many regions of the world, it is an absolutely necessary nutritional supplement. It has many and diverse functions in the human body.

One of the interesting things about selenium is that it does not perform its functions as an element or an ion. Instead, it functions as a component of more complex compounds. In particular, it is an essential component of the 21st amino acid, selenocysteine. read more

November 7, 2016December 22, 2016

Professor Jørgen Clausen: early selenium researcher

professor J. Clausen — **Professor Jørgen Clausen was one of the first researchers to realize the importance of supplementation with selenium in regions of the world with selenium-poor soil.**

Professor Jørgen Clausen, long-time professor in the Institute for Life Sciences and Chemistry, Roskilde University Center, in Roskilde, Denmark, was one of the early researchers to do clinical studies of the effects of supplementation with selenium. As such, it seems instructive to go back and look at the research done by Dr. Clausen and his colleagues at the end of the 20th century.

Professor Clausen’s selenium studies
Basically, Professor Clausen’s research can be described in five different categories:

Effect of selenium supplementation on the health of the elderly nursing home residents
Effect of selenium supplementation on the health of cigarette smokers
Effect of selenium supplementation on the health of patients with chronic neurologic disorders
Effect of selenium supplementation on the toxic effects of lead poisoning
Effect of selenium supplementation on the activity levels of the selenium-dependent antioxidant enzyme glutathione peroxidase

In addition, Professor Clausen was an early leader in the investigation of the absorption and health effects of various forms of inorganic and organic selenium supplements.

Selenium supplementation and smokers and oxidative stress
To understand Dr. Clausen’s interest in the effect of selenium supplementation on smokers, we must first understand the concept of oxidative stress and the related concept of oxidative damage. Oxidative stress occurs when, in the process of metabolism of oxygen, the body produces, as a by-product, various reactive oxygen species (for example: peroxide, superoxide, hydroxyl, and singlet oxygen radicals) to excess. read more

November 4, 2016December 22, 2016

Moderate selenium deficiency may increase risk of chronic disease

Pill, hand, disease — **A supplement of 100 micrograms of elemental selenium a day is able to satisfy the needs of the most critical selenoproteins.**

Moderate selenium deficiency is associated with increased risk of chronic disease: cancer, heart disease, thyroid disorder. Conversely, a selenium supplement containing one hundred (100) micrograms of selenium daily could reduce the risk of serious, age-related diseases in persons with moderate selenium deficiency, according to the known researcher Bruce Ames’ so-called triage theory.

Researchers Joyce McCann and Bruce Ames from Children’s Hospital Oakland Research Institute (CHORI) have analyzed the data from hundreds of scientific articles. They conclude that some selenium-dependent proteins that are regarded as essential for the body’s survival in the period until humans reach reproductive age are much more resistant to selenium deficiency than are other non-essential selenoproteins. read more

October 31, 2016December 22, 2016

Selenium Compounds Fight Cancer

diabetes-picture, cancer — **The body’s selenium level can be measured by using a blood sample**

In a new scientific study, Danish researchers from Copenhagen University have demonstrated that methylated selenium compounds can regulate the body’s immune system enabling it to better fight certain cancers. These selenium compounds are found in certain foods such as garlic and broccoli but also in the selenium preparations containing selenium yeast.

Certain cancers such as skin cancer, prostate cancer, and some forms of leukemia weaken the body’s immune system by overstimulating it until it eventually breaks down, giving cancer cells a free rein in the body. What this new Danish research shows is that the intake of selenium compounds that can be metabolized into methylselenol improves the immune system’s ability to fight cancer. read more

October 22, 2016December 22, 2016

Seleniumfacts.com – A New Website

Dr. Urban Alehagen, new website — Research done at the Linköping University in Sweden by Dr. Urban Alehagen and his colleagues has shown a relatively high mortality rate in elderly Swedish citizens with low selenium status. Daily supplementation with selenium and Coenzyme Q10 for five years significantly reduced the risk of death from heart disease in home-living healthy elderly Swedish citizens.

What is the idea behind a new website called seleniumfacts.com?

For the most part, what we want to do with this website is to present clinical research results from published, peer-reviewed studies of the safety and efficacy of selenium supplements.

A cousin website to the website q10facts.com
We want to try to do the same thing with seleniumfacts.com that we have been doing with q10facts.com website.

We want to report the results of human studies that have been done as randomized controlled clinical trials. We want to present the following types of information about selenium supplementation studies and selenium status:

the study design
the sample size
the composition of the sample
the selenium form and dosage
the length of the study
the confounding factors in the study
the study results
the researchers’ interpretation of the results

Intervention studies about selenium supplementation
Basically, there are two types of human studies: observational studies and intervention studies. The big difference between observational studies and intervention studies is that the researchers control the use of the independent variable in intervention studies but do not do so in observational studies. read more