Selenium supplements in the form of organic high-selenium yeast tablets provide the best cancer chemo-protection. These supplements are made using the yeast species Saccharomyces cerevisiae in a selenium-enriched growth medium. The yeast cells that produce the high selenium yeast tablets are rendered inactive. They are killed off by a heating process. Strains of the same yeast species are used to brew beer and bake bread.
Selenium supplementation and the risk of prostate cancer? What do we know? We need to be careful in interpreting the research results that we have (and we need more research), but, yes, there is evidence for an inverse association between prostate cancer risk and selenium status [Hurst 2012].
As of this writing (April 2017), the protective effect of selenium supplementation against prostate cancer seems to be found in a relatively narrow range of plasma selenium status [Hurst 2012]. Furthermore, there seems to be a U-shaped relationship between selenium status and protection against prostate cancer.
If the concentrations of selenium in the plasma are too low, there is increased risk of prostate cancer. This is a serious concern in many regions of the world.read more
The results of Dr. Larry Clark’s Nutritional Prevention of Cancer trial showed the efficacy of selenium supplementation in reducing the risk of colon cancer, lung cancer, and prostate cancer. Now, a meta-analysis of 69 studies shows that higher selenium exposure is associated with reductions in the risk of breast cancer, lung cancer, and prostate cancer.
Authors of a recent meta-analysis of 69 studies of selenium exposure and cancer risk have concluded that high selenium exposure can reduce cancer risk, especially high selenium exposure that is reflected in high plasma or serum selenium status and/or in high toenail concentrations [Cai 2016]. Admittedly, higher selenium intakes (as compared to lower selenium intakes) can affect different forms of cancer differently. We still need more research to sort out which forms and dosages of dietary and supplemental selenium are most effective at reducing cancer risk. In this article, I want to summarize the findings of Dr. Xianlei Cai and colleagues.
What is a meta-analysis of selenium exposure and cancer risk? A meta-analysis is a research method of combining the data from several selected research studies to reach conclusions that have greater statistical power. In the present case, Cai et al selected 69 studies that met their inclusion criteria. Each one of the 69 selected studies had the following characteristics:read more
A study of serum selenium levels and supplementation with a patented organic selenium yeast preparation shows an association between serum selenium concentrations and the rate of deaths from heart disease in healthy elderly study participants.
There have been two noteworthy discoveries from a recent randomized controlled trial conducted by Dr. Urban Alehagen of Linköping University (Sweden) and his colleagues.
Firstly, people with low concentrations of selenium in their blood were found to be at significantly higher risk of death from heart disease.
Secondly, a combination of a patented high selenium yeast supplement and a proven Coenzyme Q10 supplement taken daily for four years provided significant protection against heart disease in people with low serum selenium status.
The KiSel-10 study of cardiovascular mortality The study enrolled 668 healthy elderly individuals aged 70-80 years. The study was well-designed and well-executed. One group of 219 randomly selected individuals received 200 micrograms of selenized yeast tablets and 200 milligrams of Coenzyme Q10 capsules daily for four years. A second randomly assigned group of 222 individuals received matching placebos. The remaining group of 227 individuals received no treatment at all.read more
Daily nutritional supplementation with a combination of organic high-selenium yeast and Coenzyme Q10 for four years slowed the decline of heart function that is frequently associated with ageing.
The heart muscle tissue is frequently the first tissue in humans to suffer damage caused by selenium deficiency. When the cell membranes in the heart muscle tissue are damaged by the action of harmful free radicals (this is called oxidative damage), many of the healthy heart muscle cells are replaced by fibrous tissue. The resulting condition is called cardiomyopathy.
Cardiomyopathy is a disease of the heart muscle in which the heart is enlarged, thick, and rigid [Mayo Clinic]. As the cardiomyopathy worsens, the weakened heart muscle is less and less able to pump adequate quantities of blood to carry oxygen and nutrients to the cells and tissues throughout the body. Eventually, symptoms such as shortness of breath, early fatigue, and swelling in the legs and feet and abdomen appear, the symptoms of chronic heart failure. read more
Statin medications. What do we know? Yes, the statins are good at inhibiting the body’s own production of cholesterol. But the statins have the unintended side-effect of also inhibiting the body’s production of Coenzyme Q10 and of inhibiting the body’s ability to form selenoproteins. The inhibition of Coenzyme Q10 and selenoprotein production may lead to premature ageing and to degenerative diseases.
Statin medications: good news and bad news? On the one hand, statin medications are effective at reducing cholesterol levels, and, are good, apparently, at reducing the number of deaths from heart attacks. On the other hand, we have seen a very considerable rise in the number of cases of chronic heart failure … in the same period that statin medications have been prescribed. Drs. Okuyama and Langsjoen and their colleagues have explained the pharmacological mechanisms by which this medical paradox may be occurring [Okuyama].
Statins inhibit the body’s production of Coenzyme Q10 Okay, I was aware of the evidence from well-designed studies linking the taking of statin medications to decreased plasma levels of Coenzyme Q10. Coenzyme Q10 is an important factor in cellular energy production and is an important lipid-soluble antioxidant [Folkers, Littarru, McMurray]. And I knew that the energy-deprived heart is a failing heart [Folkers, Molyneux, Mortensen]. So, I knew that anyone taking a statin medication needs to talk to his or her cardiologist about taking a good Coenzyme Q10 supplement.read more
Dietary intakes of selenium vary considerably from person to person and region to region. Selenium supplements are necessary to raise selenium status sufficiently to prevent oxidative damage to the cells, to improve immune function, and to reduce the risk of cancer and heart disease.
How much selenium from food and supplements do we need on a daily basis? Which bio-markers of optimal selenium status seem to be most useful to answer this question? Dr. Rachel Hurst and Dr. Susan J. Fairweather-Tait, Norwich Medical School, United Kingdom, and their colleagues set out to find answers. The design of their study is very interesting.
They enrolled 119 healthy British men and women aged 50 – 64 years in a randomized, double-blind, placebo-controlled study that lasted 12 weeks [Hurst]. They excluded the following persons from the study:
smokers
overweight people
people with already high plasma selenium status
people with long-term illnesses
people on various medications
people unwilling to discontinue taking vitamins and herbal remedies at least one month prior to the start of the study
selenium-enriched yeast tablets containing 50, 100, or 200 micrograms of a patented organic selenium (SelenoPrecise® preparation delivered by Pharma Nord, Denmark)
selenium-enriched onion meals that provided the equivalent of 50 micrograms of selenium per day
unenriched onion meals that provided the equivalent of less than 4 micrograms of selenium per day
Measurements of selenium Remember: Selenium is a trace element. We measure its intake in micrograms per day, not milligrams. We measure selenium status in plasma and serum in terms of micrograms per liter (or equivalently, in nanograms per milliliter). Selenium in toenails or hair, then, we measure in micrograms per gram.read more
Selenium is a by-product of the mining and refining of copper. There are no sites in the world for the mining of selenium alone. Given its relative scarcity and its many uses — industrial and agricultural as well as nutritional — selenium for supplements will surely be more expensive in the future, and there may well be shortages of it in the future. Accordingly, it is important for us to use it wisely and to conserve it.
Selenium is an important micronutrient. It is essential for life for both people and animals. The body cannot synthesize selenium and is dependent upon the selenium that it can get from food. In many regions of the world, there is too little selenium in the soil and in the food, and supplementation is necessary for optimal health.
Regions with selenium-poor soil In many regions of the world, the content of selenium in the soil is quite low. In large parts of Asia, China in particular, and in much of Europe and the Middle East, there are low levels of selenium in the soil.
Plants accumulate inorganic selenium from the soil and convert it to organic selenium. In that way, the selenium enters the food chain. For example, cows eat grass containing selenium, and the some of the selenium enters the meat and the milk of the cows. People eat the meat and drink the milk. Too little selenium in the soil means too little selenium in the food.read more
Baker’s yeast and brewer’s yeast and high selenium yeast … all strains of the same species of yeast … Saccharomyces cerevisiae … High selenium yeast preparations are the most effective form of selenium supplements. The yeast in the tablets is dead and inactive. There is no risk of a yeast infection from a high selenium yeast preparation.
The trace element selenium is an essential component of the selenium-dependent enzymes called selenoproteins. We need these selenoproteins for the optimal biological functioning of our cells. Specifically, we need adequate daily intakes of selenium for the protection of cellular DNA, for successful reproduction, for proper thyroid gland function, for protection against infections, for anti-oxidative protection against the damage caused by free radicals, and for the prevention of cancer and heart disease.
What form of selenium is best? Many of us cannot get enough selenium in our diets, especially if we do not regularly eat Brazil nuts (very high in selenium) or if we eat relatively little meat and fish. However, there are various supplemental forms of selenium available to us as consumers.read more
The research base for supplementation with selenium shows the need for adequate daily selenium intakes and adequate selenium status. The formulation and the dosage of the selenium supplement are very important.
Daily selenium intakes? We need to get this essential trace element – selenium — in our diets and in our supplements because our bodies cannot make it for us. The work of Dr. Gerhard N. Schrauzer, Dr. Raymond J. Shamberger, and Dr. Douglas V. Frost has shown that there is an inverse relationship between our selenium status and the risk of cancer mortality. Animal studies show an inverse correlation between selenium status and incidence of cancer. Observational studies show lower risk of various types of cancer with higher selenium status.
Intervention studies of selenium supplementation and cancer Clinical studies in China Large interventional studies in China, a region of the world with selenium-poor soils and foodstuffs, have shown that selenium supplements protect against hepatitis B virus and primary liver cancer [Yu] and that supplementation with a combination of selenium and other antioxidants reduces cancer incidence and mortality in a region characterized by high cancer mortality rates [Blot].read more
The Bonelli study showed that a selenium-based antioxidant supplement combination reduces the risk of developing new adenomatous polyps in the large intestine following the removal of colorectal polyps. Adenomas, if not prevented or removed, can develop into colorectal cancer tumors.
Dr. Luigina Bonelli and a team of researchers in Genoa, Italy, were motivatedby the following set of compelling facts:
Colorectal cancer was the second leading cause of cancer death in Europe.
Adenomas in the colon (adenomas are benign tumors, which sometimes transform to malignant tumors) were known to be precursors of colorectal cancer.
Patients who had undergone a colonic polypectomy (removal of an adenomatous polyp) had an increased risk of developing colorectal cancer and needed to have periodic follow-up colonoscopies.
Increased risk of developing adenomas was equated with increased risk of developing colorectal cancers.
Observational studies indicated that there was an association between the plasma or serum concentrations of several antioxidant substances including selenium and the risk of colorectal cancer.
In some intervention studies, supplementation with selenium was associated with reductions in the incidence of colorectal cancer.
The time was right to start a large study of the effectiveness of selenium and other antioxidants in reducing the risk of colorectal cancer.
Selenium to reduce the risk of colorectal cancer Dr. Bonelli and her colleagues wanted to see if daily supplementation with a combination of antioxidants including selenium could reduce the risk of recurrent adenomas in patients who had had one or more adenomatous polyps removed. The researchers designed a randomized, double-blind, placebo-controlled clinical trial and, over the period of many years, they enrolled a total of 411 patients who had undergone a polypectomy.read more
This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Cookie settingsACCEPT
Privacy & Cookies Policy
Privacy Overview
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
